SpecPro offers in depth, insightful, and custom-purposed statistical analysis of various data including biological, ecological, and toxicological research.
Working directly with the Environmental Protection Agency (EPA) SpecPro has comprehensive capabilities including:
- Experimental Design
- Dynamic Modeling and Simulation
- Quantification and Assessment of Statistical Significance
- Statistical Modeling such as Nonlinear Regression, Power Analysis, Estimates of Critical Points of Departure, and Correlation Analysis
- Methodology Comparison and Effectiveness Testing
Our team works independently or directly with researchers to design experiments, determine statistical significance parameters, analyze results, and publish research papers outlining results.
Some examples of published works include:
- Haselman J, JW Nichols, KZ Mattingly, MW Hornung, SJ Degitz. 2023. A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae. Mathematical Biosciences 362:109021.
- Jensen Brickley MA, L Glimsdal, A Johnson, E Stacy, K Santana-Rodriguez, KZ Mattingly, DL Villeneuve, R Hockett, B Blackwell, J Cavallin, CA LaLone. New Approach Methods Enhance Understanding of Chlorantraniliprole Toxicity Across Species. Environmental Toxicology and Chemistry. Accepted.
- LaLone CA, DJ Blatz, MA Jensen, SM Vliet, S Mayasich, KZ Mattingly, TR Transue, W Melendez, A Wilkinson, CW Simmons, C Ng. 2023. From protein sequence to structure: the next frontier in cross‐species extrapolation for chemical safety evaluations. Environmental Toxicology and Chemistry 42(2):463-74.
- Mayasich SA, MR Goldsmith, KZ Mattingly, CA LaLone. 2023. Combining in vitro and in silico New Approach Methods to investigate type 3 iodothyronine deiodinase inhibition across species. Environmental Toxicology and Chemistry 42(5): 1032-1048.
- Schaupp CM, EM Maloney, KZ Mattingly, JH Olker, DL Villeneuve. 2023. Comparison of in silico, in vitro, and in vivo derived toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment. Toxicological Sciences 195(2):145-154.